Get a Simplicef prescription for dogs
Simplicef is a prescription antibiotic used to treat skin infections in dogs. Get a prescription online for just $35—no in-person vet visit needed.
- Same-day visits available
- Licensed vets in your state
- 80% cheaper than an in-person visit


How to get prescriptions online with Pawp
Pawp makes it easy to get pet prescriptions online. As a member, you can chat with a licensed vet, get your pet evaluated, and receive an Rx, all from home.
Step 1
Start your free trial with Pawp
Pawp members get 24/7 on-demand vet care and can book an Rx visit at anytime.

Step 2
Video chat with a local vet
Step 3
Get your prescription
Step 4
Shop your preferred pharmacy
What is Simplicef?

Simplicef (cefpodoxime proxetil) is a broad-spectrum antibiotic used to treat bacterial skin infections in dogs, including wounds, abscesses, and pyoderma.

Why vets prescribe Simplicef for dogs
- Treats common skin infections like wounds and abscesses
- Effective against staph and other common bacteria
- Once-daily dosing makes administration simple
- Often used for deep and superficial pyoderma
What is Simplicef used for in dogs?
Bacterial skin infections
Used to treat sores, redness, and lesions caused by bacteria
Pyoderma
Effective for deep and surface-level bacterial skin issues
Post-injury infection control
Prescribed after bites, wounds, or scratches become infected
Hot spots
Helps heal irritated, bacteria-prone skin
Ear fold infections
Sometimes used when external infections affect skin near ears
Recurring infections
Supports dogs who have repeated skin infections due to allergies or moisture
What Pawp members are saying
Download the Pawp app to get started
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- Emergency Protection
- Pet health monitoring
Frequently Asked Questions
What does Simplicef treat in dogs?
How is Simplicef given?
Are there side effects with Simplicef?
How quickly does Simplicef work?